New publication in NBD shows healthy systemic mitochondria in patients with ocular hypertension

Excited to see our paper published in the Neurobiology of Disease. We show for the first time that some patients with high eye pressure who haven’t developed glaucoma have very healthy mitochondria in their blood. Mitochondria are the batteries of cells – they produce the energy the cells need to survive. This study suggests that systemic mitochondrial efficiency is associated with resistance to developing glaucoma and raises the possibility that new treatments that make energy production more efficient may protect against glaucoma.

Representative electron microscopy images of lymphocytes from the study participants (glaucoma left, ocular hypertension right). The mitochondria are highlighted with black arrows and are more elongated and healthier in individuals with ocular hypertension as compared to patients with glaucoma.